Research at the Hubrecht Institute focuses on developmental biology and stem cells on the organismal, cellular, genetic, genomic and proteomic levels. A variety of biological processes are studied, particularly those concerning the embryonic development of animals and the development and homeostasis of organs in adult animals. Developmental biologists are interested in the mechanism that enables an organism to grow from a single fertilized egg into a fully formed adult. Stem cell research is closely linked to developmental biology. Gaining a basic understanding of development and stem cells will provide insight into (human) disease, such as cancer.
De Alexander van Oudenaarden Groep gebruikt een combinatie van experimentele, wiskundige en theoretische benaderingen om kwantitatief inzichtelijk te maken hoe individuele cellen keuzes maken. De focus van het onderzoek ligt op stamcel- en ontwikkelingsbiologie. De groep is in het bijzonder geïnteresseerd hoe cellen netwerken van genen inzetten om toch robuuste keuzes te maken zelfs als er grote fluctuaties zijn in gen-expressie.
Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. His postdoctoral work (1986-1989) was done with Cox Terhorst at the Dana-Farber Cancer Institute of the Harvard University, Boston, USA.
From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. Since 2002, he is director of the Hubrecht Institute in Utrecht .
Hans Clevers has been a member of the Royal Netherlands Academy of Arts and Sciences since 2000 and is the recipient of several awards, including the Dutch Spinoza Award in 2001, the Swiss Louis Jeantet Prize in 2004, the Memorial Sloan-Kettering Katharine Berkan Judd Award in 2005, the Israeli Rabbi Shai Shacknai Memorial Prize in 2006, and the Dutch Josephine Nefkens Prize for Cancer Research, the German Meyenburg Cancer Research Award in 2008, the Dutch Cancer Society Award in 2009, the United European Gastroenterology Federation (UEGF) Research Prize in 2010 and the Ernst Jung-Preis für Medizin in 2011. He obtained an ERC Advanced Investigator grant in 2008. He is Chevalier de la Legion d'Honneur since 2005.
Produced by Fast Facts
With the support of the Hubrecht Institute
Thanks to the coworkers at the Hubrecht Institute, Jan Wink and Sarah Jiska at the Wilhelmina Children's Hospital, Frans van den Hoven & Marc Stenders of the Utrecht University Museum
With images from: European Molecular Biology Laboratory (Heidelberg), Prof. Dr. Marie-José Goumans (LUMC), NYMUS3D, Spieren voor Spieren, patient: Lennart Colen
Made by: Jasmijn Snoijink 2013
In cooperation with
Camera & editing: Wouter Boes and John Treffer
Music: FrithMedia and Daan van West
Graphic design: SproetS