Knipscheer: Een blokkade op de DNA snelweg
A roadblock on the DNA highway
Understanding DNA crosslink repair
According to Puck Knipscheer, proteins work together as fascinating little machines, each with a different function. And these machines can fix some of the most complicated damage our bodies can encounter: DNA crosslinking. The Knipscheer Group seeks to unravel which and how proteins repair this DNA damage.
Puck Knipscheer received her PhD in 2007 from the Netherlands Cancer Institute/Erasmus University. In the laboratory of Prof. Titia Sixma she used X-ray crystallography and biochemical approaches to study the regulation of SUMO modification. With a fellowship from the Dutch Cancer Society she subsequently joined Harvard Medical School in Boston as a postdoctoral fellow. In the laboratory of Prof. Johannes Walter she used Xenopus laevis egg extracts to investigate the biochemical details of a poorly understood DNA repair pathway. For her postdoctoral and PhD studies she received the Heineken Young Scientist Award for Biochemistry and Biophysics 2010. In 2011 she started her laboratory at the Hubrecht Institute where she studies molecular mechanisms and regulation of DNA repair using Xenopus.
Made by: Aline Idzerda 2011
Camera & editing: John Treffer
Music: Daan van West
Graphic design: SproetS
Thanks to the coworkers at the Hubrecht Institute, the researchers at the Puck Knipscheer Group